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Abemaciclib (LY2835219) mesylate

Product #: TS0326
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Details

l  General Information

Product Name

Abemaciclib mesylate

General description

Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6.

Synonym

N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine; methanesulfonic acid; LY2835219 mesylate

Purity

≥98.0%(HPLC)

CAS Number

1231930-82-7

Formula

C27H32F2N8·CH4O3S

Molecular Weight

602.7

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥20mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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