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Sorafenib

Product #: TL0082
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Details

l  General Information

Product Name

Sorafenib

General description

Sorafenib is a synthetic compound targeting growth signaling and angiogenesis.

Synonym

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; Nexavar; BAY 43-9006;

Purity

≥99%(HPLC)

CAS Number

284461-73-0

Formula

C21H16ClF3N4O3

Molecular Weight

464.829

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to pale brown powder

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Very slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Sorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.

Application

1.Protein Kinase Inhibitors

2.Antineoplastic Agents

l  Packaging & Storage

Packaging

250mg; 1g

Storage temp.

0-5℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 


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